1. Maejima Y, Horita S, Yokota S, Ono T, Proks P, Yoshida-Komiya H, Ueta Y, Mishimori K, Misaka S, Shimomura K. Identification of oxytocin receptor activating chemical components from traditional Japanese medicines. J Food Drug Anal 2021 (in press).
2. Higa A, Takahashi N, Hiyama G, Tamura H, Hoshi H, Shimomura K, Watanabe S, Takagi M. High-throughput in vitro assay using patient-derived tumor organoids. J Vis Exp 14, 2021.
3. Maejima Y, Yokota S, Shimizu M, Horita S, Kobayashi D, Hazama A, Shimomura K. The deletion of glucagon-like peptide-1 receptors expressing neurons in the dorsomedial hypothalamic nucleus disrupts the diurnal feeding pattern and induces hyperphasia and obesity. Nutr Metab (Lond) 18, 58, 2021.
4. Zhao J, Imai R, Ukon N, Shimoyama S, Tan C, Maejima Y, Omiya Y, Takahashi K, Non G, Zhao S, Ito H, Shimomura K. Evaluation of effect of Ninjin’yoeito on regional brain glucose metabolism by 18F-FDG autoradiography with insulin loading in aged mice. Front Nutr 8, 657663, 2021.
5. Takahashi N, Higa A, Hiyama G, Tamura H, Hoshi H, Dobashi Y, Katahira K, Ishihara H, Takagi K, Goda K, Okabe N, Muto S, Suzuki H, Shimomura K, Watanabe S, Takagi M. Construction of in vitro patient-derived tumor models to evaluate anticancer agents and cancer immunology. Oncol Lett 21, 406, 2021.
6. Zhao J, Tan C, Imai R, Ukon N, Shimoyama S, Maejima Y, Omiya Y, Takahashi K, Ito H, Non G, Zhao S, Shimomura K. Evaluation of organ glucose metabolism by 18F-FDG accumulation with insulin loading in aged ice compared with young normal mice. Sci Rep 11, 7421, 2021.
7. Gonda K, Horita S, Maejima Y, Takenoshita S, Shimomura K. Soluble interleukin-2 receptor as a predictive and prognostic marker for patients with familial breast cancer. Sci Prog 104, 368504211039590, 2021.
8. Horita S, Ono T, Gonzalez-Resines S, Ono Y, Yamachi M, Zhao S, Domene C, Maejima Y, Shimomura K. Structure based analysis of KATP channel with DEND syndrome mutation in murine skeletal muscle. Sci Rep 11, 6668, 2021.
1. Shimazaki S, Kuroda J, Shimomura K, Misaka S. Urinary excertion of nadorol as a possible in vivo probe fro drug interactions involving p-glycoprotein. J Clin Pharmacol 2020 (ahead of print).
2. Iseki Y, Ono Y, Hibi C, Tanaka S, Takeshita S, Maejima Y, Kurokawa J, Murakawa M, Shimomura K, Sakamoto K. Opening of intermediate conductance Ca2+-activated K+ channels in C2C12 skeletal muscle cells increases the myotube diameter via the Akt/mTOR pathway. J Pharmacol Exp Ther 2020 (ahead of print).
3. Horiai M, Otsuka A, Hidema S, Hiraoka Y, Hayashi R, Miyazaki S, Furuse T, Mizukami H, Teruyama R, Tanyra M, Bito H, Maejima Y, Shimomura K, Nishimori K. Targeting oxytocin receptor (Oxtr)-expressing neurons in the lateral septum to restore social novelty in autism spectrum disorder mouse models. Sci Rep 10, 22173, 2020.
4. Shimizu M, Manome T, Kumami M, Matsumura K, Kanai K, Shimomura K, Maejima Y. Detection of NUCB2/nesfaftin-1 in cerebrospinal fluid of multiple sclerosis patients. Aging (Albany) 2020 (ahead of print).
5. Odouri OS, Murao N, Shimomura K, Takahashi H, Zhang Q, Dou H, Sakai S, Minami K, Chanclon B, Guida C, Kothegala L, Tolo J, Maejima Y, Yokoi N, Minami Y, Miki T, Rorsman P, Seino S. Gs/Gq signalling switch in b cell defines incretin effectiveness in diabetes. J Clin Invest 130, 6639-6655, 2020.
6. Misaka S, Ono Y, Uchida A, Ono T, Abe O, Ogata H, Sato H, Suzuki M, Onoue S, Shikama Y, Shimomura K. Impact of green tea catechin ingestion on the pharmacokinetics of lisinopril in healthy volunteers. Clin Transl Sci 2020 (ahead of print).
7. Hidema S, Kikuchi S, Takata R, Yanai T, Shimomura K, Horie K, Nishimori K. Single admknistration of resveratrol improves social behaviour in adult mouse models of autism spectrum disorder. Biosci Biotechnol Biochem 84, 2207-2214, 2020.
8. Maejima Y, Yokota S, Horita S, Shimomura K. Early life high-fat diet exposure evokes normal weight obesity. Nutr Metab (Lond) 17. 48, 2020.
9. Imai R, Horita S, Ono Y, Hagihara K, Shimizu M, Maejima Y, Shimomura K. Gashajinkigan, a tradisional Japanese medicine, suppresses voltage-gated sodium channel Nav 1.4 currents in C2C12 cells. Biores Open Access 6, 116-120, 2020.
10. Misaka S, Abe O, Ono T, Ono Y, Ogata H, Miura I, Shikama Y, Fromm MF, Yabe H, Shimomura K. Effects of single green tea ingestion on pharmacokinetics of nadolol in healthy volunteers. Br J Clin Pharmacol 86, 2314-2318, 2020.
11. Maejima Y, Horita S, Otsuka A, Hidema S, Nishimori K, Shimomura K. Oral oxytocin delivery with proton pump inhibitor pretreatment decreases food intake. Peptides 128, 170312, 2020.
12. Misaka S, Shimomura K. Atrovastatin-green tea interaction: Possible mechanisms are complicated, but clinical relevance not? Eur Drug Metab Pharmacokinet 45, 423-425, 2020.
13. Ono Y, Maejima Y, Saito M, Sakamoto K, Horita S, Shimomura K, Inoue S, Kotani J. TAK-242, a specific inhibitor of Toll-like receptor 4 signalling, prevents endotoxemia-induced skeletal muscle wasting in mice. Sci Rep 10, 694, 2020.
1. Maejima Y, Kato S, Horita S, Ueta Y, Takenoshita S, Kobayashi K, Shimomura K. The hypothalamus to brainstem circuit suppresses late-onset body weight gain. Sci Rep 9, 18360, 2019.
2. Gonda K, Akama T, Nakamura T, Hashimoto E, Kyoya N, Rokkaku Y, Marjima Y, Horita S, Tachibana K, Abe N, Ohtake T, Shimomura K, Kono K, Saji S, Takenoshita S, Higashihara E. Cluster of differenciation 8 and programmed cell death ligand 1 expression in triple-negative breast cancer combined with autosomal dominant polycystic kidney disease and tuberous sclerosis complex: a case report. J Med Case Rep 13, 381, 2019.
3. Gonda K, Yaginuma K, Rokkaku Y, Horita S, Maejima Y, Shimomura K. Association between cognitive impairment patient with solid cancer and insulin resistance. BMC Res Notes 12 705, 2019.
4. Jojima T, Wakamatsu S, Kase M, Iijima T, Maejima Y, Shimomura K, Kogai T, Tomaru T, Usui I, Aso Y. The SGLT2 inhibitor canagloflozin prevents carcinogenesis in a mouse model of diabetes and non-alcholic steatihepatitis-related hepatocarcinogenesis: association with SGLT2 expression in hepatocellular carcinoma. Int J Mol Sci 20 E5237, 2019.
5. Maejima Y, Yokota S, Horita S, Shimomura K. The undeveloped properties of GABA neurons in the ventral tegmental area promote energy intake for growth in juvenile rats. Sci Rep 9, 11848, 2019.
6. Takahashi N, Hoshi H, Higa A, Hiyama G, Tamura H, Ogawa M, Takagi K, Goda K, Okabe N, Muto S, Suzuki H, Shimomura K, Watanabe S, Takagi M. An in vitro system for evaluating molecular targeted drugs using lung patient-derived tumor organoids. Cells 20, 8, E481, 2019.
7. Momma T, Gonda K, Akama Y, Endo E, Ujiie D, Fujita S, Maejima Y, Horita S, Shimomura K, Saji S, Kono K, Yashima R, Watanabe F, Sugano K, Nomizu T. MLH1 germline mutation associated with Lynch syndrome in a family followed for more than 45 years. BMC Med Genet 20, 67, 2019.
8. Satake S, Shimura T, Ono T, Shimomura K, Takenoshita S, Kono K. Noninvasive continuous blood pressure monitoring using microelectrochemical system technology. Blood Press Monit 2019 (ahead of print).
9. Otsuka A, Jinguji A, Maejima Y, Kasahara Y, Shimomura K, Hideme S, Nishimori K. LGR4 is essential for R-spondin 1-mediated suppression of food intake via pro-opiomelanocortin. Biosci Biotechnol Biochem 27, 1-7, 2019.
10. Aso Y, Kato K, Sakurai S, Kishi H, Shimizu M, Jojima T, Iijima T, Maejima Y, Shimomura K, Usui I. Impact of dapagliflozin, an SGLT2 inhibitor, on serum levels of soluble dipeptidyl peptidase-4 in patients with type 2 diabetes and non-alcoholic fatty liver disease. Int J Clin Pract 2019 (ahead of print).
11. Horita S, Kataoka M, Kitamura N, Miyakawa T, Ohtsuka J, Maejima Y, Shimomura K, Nagata K, Shimizu S, Tanokura M. Structural basis of different substrate preferences of two old yellow enzymes from yeasts in the asymmetric reduction of enone compounds. Biosci Biotechnol Biochem 83, 456-462, 2019.
12. Imai R, Yokota S, Horita S, Ueta Y, Maejima Y, Shimomura K. Excitability of oxytocin neurons in paraventricular nucleus is regulated by voltage-gated potassium channels Kv4.2 and Kv4.3. Biosci Biotechnol Biochem 83, 202-211, 2019.
1. Horita S, Kataoka M, Kitamura N, Miyakawa T, Ohtsuka J, Maejima Y, Shimomura K, Nagata K, Shimizu S, Tanokura M. Structural basis of different substrate preferences of two old yellow enzymes from yeasts in the asymmetric reduction of enone compounds. Biosci Biotechnol Biochem 2018 (ahead of print).
2. Imai R, Yokota S, Horita S, Ueta Y, Maejima Y, Shimomura K. Excitability of oxytocin neurons in paraventricular nucleus is regulated by voltage-gated potassium channels Kv4.2 and Kv4.3. Biosci Biotechnol Biochem 2018 (ahead of print).
3. Gonda K, Tachiya Y, Hatakeyama Y, Momma T, Tamaoki T, Maejima Y, Rokkaku Y, Saji S, Shimomura K, Kono K. Poland syndrome accompanied by internal iliac artery supply disruption sequence: a case report. J Med Case Rep 26, 12, 312. 2018.
4. Maejima Y, Yokota S, O’Hashi R, Aoyama M, Shimomura K. The effect of avertin anesthesia and mixture of three types of anesthetic agents on food intake and body weight in high fat-induced obese male and female mice. Exp Anim (ahead of print) 2018.
5. Imai R, Misaka S, Horita S, Yokota S, O’hashi R, Maejima Y, Shimomura K. Memantine has no effect on KATP channels in pancreatic beta cells. BMC Res Notes 11, 614, 2018.
6. Misaka S, Shimomura K. Similar effect of quercetin on CYP2E1 and CYP2C9 activates in humans? Eur J Clin Pharmacol (ahead of print) 2018.
7. Werba JP, Misaka S, Giroli MG, Shimomura K, Amato M, Simonelli N, Vigo L, Tremoli E. Update of green tea interactions with cardiovascular drugs and putative mechanisms. J Food Drug Anal 26 S72-77, 2018.
8. Maejima Y, Yokota S, Nishimori K Shimomura K. The anorexigenic neural pathways of oxytocin and its clinical implication. Neuroendocrinology 107, 91-104, 2018.
9. Kato S, Fukabori R, Nishizawa K, Okada K, Yoshioka N, Sugawara M, Maejima Y, Shimomura K, Okamoto M, Eifuku S, Kobayashi K. Action selection and flexible switching controlled by the intralaminar thalamic neurons. Cell Reports 22, 2370-2382, 2018.
1. Maejima Y, Aoyama M, Sakamoto K, Jojima T, Aso Y, Takasu K, Takenoshita S, Shimomura K. Impact of sex, fat distribution and initial bod weight on oxytocin’s body weight regulation. Scientific Reports (accepted) 2017.
2. Maejima Y, Horita S, Kobayashi D, Aoki M, O’hashi R, Imai R, Sakamoto K, Mori M, Takasu K, Ogawa K, Takenoshita S, Zhao S, Hazama A, Shimomura K. Nesfatin-1 inhibits voltage gated K+ channels in pancreatic beta cells. Peptides (ahead of print) 2017.
3. Ono Y, Sakamoto K. Lipopolysaccaride inhibits myogenic differenciation of C2C12 myoblasts through the Toll-loke receptor 4-nuclear factor kB signalling pathway and myoblast-derived tumor necrosis factor alpha. PLOS one 12 e0182040 2017.
4. Maejima Y, Takahashi S, Takasu K, Takenoshita S, Ueta Y, Shimomura K. Orexin action on oxytocin neurons in the paraventricular nucleus of the hypothalamus. NeuroReport 28, 360-366, 2017.
5. Shimomura K. Maejima Y. Mutation in KATP channel and neonatal diabetes. Intern Med (accepted), 2017.
6. Tokita Y, Maejima Y, Shimomura K, Takenoshita S, Ishiyama N, Akuzawa M, Shimomura Y, Nakajima K. Non-alcoholic fatty liver disease is a risk factor for type 2 diabetes in middle-aged Japanese men and women. Intern Med 56,763-771, 2017.
1. Brereton M, Rohm M, Shimomura K, Holland C, Tornovsky-Babeay S, Dadon D, Iberl M, Chibalina M, Lee S, Glaser B, Dor Y, Rorsman P, Clark A, Ashcroft F. Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells Nature Communications 7, 13496 2016.
2. Hugill A, Shimomura K, Cox RD. Islet insulin secretion measurements in mouse. Curr Protoc Mouse Biol 6, 256-271, 2016.
3. Maejima Y, Kumamoto K, Takenoshita S, Shimomura K. Projection from a single NUCB2/nesfatin-1 neuron in the paraventricular nucleus to different brain regions involved in feeding. Brain Struct Funct 221, 4723-4731, 2016.
4. Sakamaki K, Maejima Y, Tokita Y, Masamura Y, Kumamoto K, Akuzawa M, Nagano N, Nakajima K, Shimomura K, Takenoshita S, Shimomura Y. Impact of visceral fat area measured by dual impedance method on diagnostic components of metabolic diseases in a middle-aged Japanese population. Internal Med 55, 1691-1696, 2016.
5. Misaka S, Knop J, Singer K, Hoier E, Keiser M, Müller F, Glaeser H, König J, Fromm MF. The non-metabolized β-blocker nadolol is a substrate of OCT1, OCT2, MATE1, MATE2-K and P-glycoprotein, but not of OATP1B1 and OATP1B3. Molecular Pharmaceutics, 13, 512-519, 2016.
1. Werba JP, Misaka S, Giroli MG, Yamada S, Cavalca V, Kawabe K, Squellerio I, Laguzzi F, Onoue S, Veglia F, Myasoedova V, Takeuchi K, Adachi E, Inui N, Tremoli E, Watanabe H. Overview of green tea interaction with cardiovascular drugs. Current Pharmaceutical Design, 21, 1213-1219, 2015.
2. Shimizu T, Suzuki S, Sato A, Nakamura Y, Ikeda K, Saitoh S, Misaka S, Shishido T, Kubota I, Takeishi Y. Cardio-protective effects of pentraxin 3 produced from bone marrow-derived cells against ischemia/reperfusion injury. Journal of Molecular and Cellular Cardiology, 89, 306-313, 2015.
3. Knop J, Misaka S, Singer K, Hoier E, Müller F, Glaeser H, König J, Fromm MF. Inhibitory effects of green tea and (–)-epigallocatechin gallate on transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-glycoprotein. Plos One, 10, e0139370, 2015.
4. Santoso P, Maejima Y, Kumamoto K, Takenoshita S, Shimomura K. Central action of ELABELA reduces food intake and activates arginine vasopressin and corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. NeuroReport 26, 820-826, 2015.
5. Arredouani A, Ruas M, Collins SC, Parkesh R, Clough F, Pillinger T, Coltart G, Rietdorf K, Royle A, Johnson P, Braun M, Zhang Q, Sones W, Shimomura K, Norgan AJ, Lewis AM, Chuang KT, Tunn R, Gadea J, Teboul L, Heister PM, Tynan PW, Bellomo EA, Rutter GA, Rorsman O, Churchill GC, Parrington J, Gallione A. NAADP and endolysosomal two-pore channels modulate membrane excitability and stimulus-secretion coupling in mouse pancreatic beta cells. J Biol Chem 290, 21376-21392, 2015.
6. Nohara A, Maejima Y, Shimomura K, Kumamoto M, Takahashi M, Akuzawa M, Negishi M, Ishiyama N, Nagano N, Aso Y, Takenoshita S, Shimomura Y. Self-awareness of fast eating and its impact on diagnostic components of metabolic syndrome among middle-aged Japanese males and females. Endocrine Regulations 49, 91-96, 2015.
7. Maejima Y, Hasegawa S, Horita S, Kumamoto K, Galbanovskis J, Takenoshita S, Shimomura K. Water intake disorder in DEND syndrome afflicted patient with R50P mutation. Endocr J. 62. 387-392, 2015.
1. Misaka S, Yatabe J, Müller F, Takano K, Kawabe K, Glaeser H, Yatabe MS, Onoue S, Werba JP, Watanabe H, Yamada S, Fromm MF, Kimura J. Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. Clinical Pharmacology and Therapeutics, 95, 432-438, 2014.
2. Yamada S, Misaka S, Ito Y, Watanabe H, Umegaki K. Effects of natural products on pharmacokinetics and pharmacodynamics of drugs. Pharma-Nutrition, AAPS Advances in Pharmaceutical Sciences Series, Gert Folkerts and Johan Garssen eds., Springer, 12, 189-211, 2014.
3. Misaka S, Müller F, Fromm MF. Clinical relevance of drug efflux pumps in the gut. Current Opinion on Pharmacology, 13, 847-852, 2013.
4. Misaka S, Miyazaki N, Fukushima T, Yamada S, Kimura J. Effects of green tea extract and (–)-epigallocatechin-3-gallate on pharmacokinetics of nadolol in rats. Phytomedicine, 20, 1247-1250, 2013.
5. Misaka S, Kawabe K, Onoue S, Giroli M, Werba JP, Watanabe H, Yamada S. Green tea extract affects cytochrome P450 3A activity and pharmacokinetics of simvastatin in rats. Drug Metabolism and Pharmacokinetics, 28, 514-518, 2013.
6. Yamada S, Taki Y, Misaka S, Okura T, Deguchi Y, Umegaki K, Watanabe H, Watanabe Y, Skinner M. Chapter 4, Pharmacokinetic and Pharmacodynamic Interaction of Functional Foods with Medicines. Bioactives in Fruit: Health Benefits and Functional Foods, Margot Skinner and Denise Hunter eds., Wiley-Blackwell , 59-80, 2013.
7. Misaka S, Miyazaki N, Yatabe MS, Ono T, Shikama Y, Fukushima T, Kimura J. Pharmacokinetic and pharmacodynamic interaction of nadolol with itraconazole, rifampicin and grapefruit juice in healthy volunteers. Journal of Clinical Pharmacology, 53, 738–745, 2013.
8. Ogata H, Yatabe MS, Misaka S, Shikama Y, Sato S, Munakata M, Kimura J. Effect of oral L-arginine administration on exhaled nitric oxide (NO) concentration in healthy volunteers. Fukushima Journal of Medical Sciences, 59, 43–48, 2013.
9. Miyazaki N, Misaka S, Ogata H, Fukushima T, Kimura J. Effects of itraconazole, dexamethasone and naringin on the pharmacokinetics of nadolol in rats. Drug Metabolism and Pharmacokinetics, 28, 356–361, 2013.
10. Misaka S, Kawabe K, Onoue S, Werba JP, Giroli M, Tamaki S, Kan T, Kimura J, Watanabe H, Yamada S. Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes. Drug Metabolism and Pharmacokinetics, 28, 244–249, 2013.
11. Misaka S, Kawabe K, Onoue S, Werba JP, Giroli M, Kimura J, Watanabe H, Yamada S. Development of rapid and simultaneous quantitative method for green tea catechins on the bioanalytical study using UPLC/ESI-MS. Biomedical Chromatography, 27, 1–6, 2013.